6年生の谷岡大輔さんが第68回日本神経化学会大会(2025/9/11-13)で発表します。
(2025/9/12@ウインクあいち、名古屋）

P2-120 妊娠期乾癬と産仔の行動

Maternal psoriasis and offspring behavior

○ Daisuke Tanioka 1，Minaka Sakuma 1，Yoshinori Otani 1， Yoichiro Iwakura 2，Masashi Fujitani 1

1 Department of Anatomy and Neuroscience Faculty of Medicine, Shimane University，

2 Research Institute for Biomedical Sciences, Tokyo University of Science

Epidemiological studies have reported that children born to mothers with autoimmune diseases, including psoriasis, are at approximately twice the risk of developing autism spectrum disorder (ASD) or attention-deficit/hyperactivity disorder(ADHD). Numerous studies have also demonstrated that interleukin-17a (IL-17a) plays a critical role in the pathogenesis of psoriasis. However, it remains unclear whether IL-17a induced by maternal psoriasis directly contributes to the development of ASD in offspring.In mouse models, maternal immune activation (MIA) during mid-gestation is known to profoundly affect fetal brain development. The imiquimod (IMQ)-induced psoriasis model, which utilizes IMQ as a TLR7 agonist, is widely used in mice. In this study, we established a pregnancy model of IMQ-induced psoriasis and conducted behavioral analyses on the adult offspring.Our findings reveal that MIA induced by IMQ application significantly reduced the total number of surviving offspring compared to the control group. Notably, this reduction was prevented in IL-17a-deficient mice. Furthermore, female offspring exhibited anxiety-like behaviors in the open field test (OFT) and increased repetitive behaviors in the marble burying test (MBT). These results suggest that IL-17a may contribute to both fetal loss and neurobehavioral alterations in offspring in the IMQ-induced MIA model.